The storyline begins with the end of the Sars epidemic in Hong Kong and the accidental death of Paul's ex-girlfriend Tracy. Paul begins a tailspin, but fortunately Frances is always there to support him. Henry appears at the beginning of Healing Hands 3 with a new girlfriend, having broken up with Annie between Healing Hands 2 and 3. However, he soon breaks up and despite initial bad impressions of Sarah, the two become friends. The drama follows the challenges that the characters face- including the medical obstacles faced by the doctors of Yan Oi hospital and the love life troubles that the various couples of the series overcome.