Tania, a girl from Patiala, moves to Kuwait and then to Las Vegas to start her movie career. The film begins with the ending of From Vegas to Macau II where the cardshark Ken’s lifelong lover-nemesis, Molly, skydives sans parachute from her private jet. She now appears to be trapped inside some sort of laser bubble — unconscious, naked and horribly airbrushed — while her admirer, mad scientist Yik Tin Hang fumes read moreabout making Ken pay. Over in Macau, Ken is busy having a meltdown over the wedding of the century of his daughter Rainbow to his godson Vincent. To help him snap out of it, his friend Mark hypnotizes him into thinking Vincent is marrying his fat cousin. Things go very wrong when Michael, the disciple of Ko Chun, phoned in with a warning to beware of Yik Tin Hang, who has hired mercenaries to kill Ken. An explosion during the wedding causes both Rainbow and Vincent to fall into a coma while Ken and Mark are accused to have engulfed DOA’s illicit money. Enraged, Ken swears to seek vengeance and to pursue the mastermind who has entangled them in his evil plans.