Matteo Domingo (Gil Cuerva) is an extraterrestrial being that disembarked on the Philippines back in the 16th century during the Spanish Colonial Era. As he ventures to aid a teenage girl, Marcella (Pauline Mendoza), from descending off a cliff, he failed to join his trip, the KMT 184.5 comet, back to his planet and is grounded on Earth for the next four centuries and counting. He possesses an almost perfect form, enhanced physical abilities that improves his vision, hearing and speed drastically, and has a rather caustic, jaded point of view with regards to human beings. As time passes by and the story folds on, Matteo is forced to employ a new identity every ten years, as his human appearance never ages.
In the present day, he disguises himself as a college professor and teaches at a nearby university. With only three months left before his much-awaited departure back to the planet where he came from, he would meet Steffi Chavez (Jennylyn Mercado), an over-confident famous Filipino star who all of a sudden becomes his adjacent condominium neighbor. Bit by bit, he finds himself mischievously entwined in her crazy and unpredictable situations, and realizes that she looks like the teenage girl he cared for and fell in love with back in the 1500s. Matteo tries to keep himself unattached from Steffi as he is going to leave the planet anytime soon, but constantly finds himself failing to do so.