The story of Triumph in the Skies 2 takes place roughly a few years after airline pilot captain Sam marries Zoe, a passenger service agent who was born with a severe heart condition. When Zoe dies, the introverted and mournful Sam resigns his position as pilot captain and spends a long vacation in England. There, he meets the heartbroken student pilot Holly, who convinces him to return to Hong Kong to join Skylette Airlines.
At Skylette, Sam meets Jayden, a boastful and womanizing captain-in-training whom Sam is in charge of examining. Their opposite personalities clash and their rivalry become even stronger when both of them develop a fondness for Holly.
Meanwhile, Sam’s younger brother Isaac meets aircraft maintenance technician Summer, Jayden’s cold and withdrawn younger sister. Summer bears a strong physical resemblance to Isaac’s deceased sister-in-law Zoe, and Isaac finds it hard to ignore her. An unfortunate experience in her childhood causes Summer to loathe her elder brother Jayden, but Isaac helps the pair patch up their relationship. Summer falls in love with Isaac, but Isaac does not want to remind Sam of his heartbroken past.
Isaac’s good friend, first officer pilot Roy is emotionally caught in relationships with two girlfriends. He confides to senior cabin crew leader Heather, whom he considers as his soul mate.
In a related story, Hong Kong national swimming team athlete Jim quits the team to earn a pilot license. He befriends the ground crew and pilots at Skylette Airlines, also falling in love with cabin crew leader Coco, now a pregnant surrogate mother.