Both
- lost their mother early
- kids had to fend for themselves (although Go Ahead adults were much nicer & heartwarming)
- had the elder brother figure that took care of the younger siblings

Both are detective cases and are focused around female centric themes in the crime solving business. Maiden Holmes seems be more broad in the sense that the female lead can somewhat fight, is a detective that can find clues, and can determine death info. In contrast, the Imperial Coroner mainly focuses own one expertise. The female lead is much more well versed in determining the causes of death and symptoms it shows through the corpse. Her explanation is much more explicit and scientifically explained in contrast to Maiden Holmes which only offer generalizations.