Puzzle

Both have main female leads that are smart, cheeky, and good a solving mysterious.

Both dramas are from the 2000's and about mystery solving.
Both have a strong female lead as the main character.

Whenever I think of puzzle I think of this series. Maybe because it the year they both were release at the same time? The theme are similar, it funny and enjoyable. Puzzle is a team of high school boys who solves mystery for their strange and bipolar teacher. Whereas the four sisters are a group of sisters solving the mysteries.

Similar genre of an after school comedy mystery of teacher and student investigating cases. Similar chaotic vibes and humor.

Similar comedy dramas about a chaotic, upbeat and nosey teacher getting into her students shenanigans. Gokusen is about delinquents while Puzzle is about mysteries.