Color Rush Season 2

In both shows the leads are socially awkward outcasts. They also idolize their popular love interest.

First Season of Color Rush 2.
The cast is a bit different but you should watch it for context.
The main couple is different but we get to know the world setting.

Both series have protagonists with a specific form of supernatural disease where only a small number of people around the world suffer from this rare disease. Both series also contain the idea that only their soulmate can help them in this disease.