In the sense either the the other lead has to accept that the lead's ambition/occupation will always come first, which he/she accepts, maybe because the other lead has the same ambition but not the skills to fulfill them.
Or, where one of the leads are simply eccentric and they have to accept that and that the other lead's love for them might be there or not from one moment to another.
I guess, in simple turns I'm looking for a romance where love is valued on opposite terms, yet finds away to be in a relationship either way.
Things I've seen that kinda fits:
Flower of Evil (haven't finished it yet) (https://mydramalist.com/54625-flower-of-evil)
Brain (https://mydramalist.com/3067-brain)