I just finished
Three Brothers and it has almost everything you are asking for, but the "likable female lead". There isn't a female lead per se in this drama, since each one of the characters have their own time to "shine" if you know what I mean. And, you're going to hate them and love them, because they change as the drama goes on.
Also, the main focus of this drama is the family of the three brothers, but the parents of the spouses are important too.
I like
Smile, You too. This one has a likeable female lead, and it has two famliles that end up leaving together and this brings them problems and bleble :P